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KMID : 0604520070330020087
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 2 p.87 ~ p.92
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The Inhibitory Effects of Acanthopeltis japonica on Melanogenesis
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Yoon Hoon-Seok
Kim Jeong-Kook
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Abstract
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To develop the skin whitening agent, we investigated the effects of Acanthopeltis japonica, a rhodophyta on the coast of Jeju island, on melanogenesis. Dried A. japonica was refluxed with 70 % aqueous ethanol and the extract was evaporated to dryness. To validate the activity as a depigmenting agent, various in vitro tests, polyphenol contents, and free radical scavenging activity were performed. In addition, cellular tyrosinase activity and protein expression of p-ERT, tyrosinase, TRP-1, and TRP-2 were measured in B16/F10 murine melanoma cells. A. japonica had low polyphenol contents and low free radicals scavenging activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. A. japonica suppressed cellular tyrosinase activity up to 86.9 % at with inhibition or tyrosinase and TRP-1 expression in -melanocyte stimulating hormone (-MSH)-treated B16/F10 melanoma cells. Our results suggest that inhibitory effects of A. japonica on melanogenesis are due to inhibiting the pathways involving -MSH-induced ERK activation. Therefore, A. japonica nay be useful as a skin whitening agent associated with the suppressive effect of melanotrophin-induced signaling pathway to inhibit melanin synthesis.
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KEYWORD
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Acanthopeltis japonica, melanogenesis, tyrosinase, skin whitening activity, ERK 1/2
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